Hypogonadism r en endokrin sjukdom dr knskrtlarna har en bristfllig funktion, vilket resulterar i fr lg eller ingen produktion av knshormoner, det vill sga till exempel testosteron eller strogen. Tillstndet leder obehandlat bland annat till bristfllig utveckling av spermier eller ggfollikler hos vuxna och bristfllig pubertet hos barn och unga.
Hypogonadism hos mn ska inte frvxlas med testosteronbrist, som kan ha andra orsaker. I synnerhet hos ldre mn kan hypogonadism antingen bero p dligt fungerande knskrtlar, eller p problem med fristtningshormonkrtlarna hypotalamus och hypofysen. Testosteronniverna kan vara lga tillflligt eller bero p andra sjukdomar, ssom diabetes, hjrtsvikt eller annan hjrt- och krlsjukdom. Testosteronaktiviteten kan vara frndrad till fljd av frndringar av knshormonbindande globulin (SHBG), som binder testosteronet till sig i blodet och gr det overksamt s lnge som bindningen kvarstr. SHBG-niverna sjunker av fetma, undervikt, akromegali, hypotyroidism, insulinresistens, med mera. Vid hypogonadism ses frhjda vrden luteiniserande hormon och follikelstimulerande hormon (hypergonadotropism) tillsammans med testosteronbrist, nr sjukdomar i hypotalamus och hypofys visar snkta sdana vrden med testosteronbristen (hypogonadotropism). I det frra fallet - primr hypogonadism - kan tillstndet bero p kromosomala avvikelser, frgiftning, missbildningar av testiklar (kryptorkism etc), trauma mot testiklar, jrnverskott, lkemedel, och frhjd temperatur vid testiklarna.[1]
Bristande funktion i ggstockarna kallas ocks ovarialsvikt.
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