Clomiphene Citrate for Low-T

Written by Dr. White, Published on August 20th, 2018

Clomiphene Citrate is an alternative to Testosterone Replacement Therapy for men looking for a way to safely restore their Testosterone Levels and improve their health, vitality, and sexual potency. It has helped many men across the country restore both their fertility and their erectile function, as well as improve their overall health and vitality. Although Clomiphene Citrate is available as a generic medication, it can also be found under the brand names Serophene and Clomid.

Download: Clomiphene Citrate for Low-T


Clomiphene Citrate was originally designed to be a fertility drug for women, but ongoing research has shown that the hormone has a tremendous impact upon Testosterone Levels in men that are suffering from Andropause or any other form of Secondary Testosterone Deficiency.

How Does Clomiphene Citrate Work?

To understand how Clomiphene Citrate works, it’s important to understand the underlying mechanisms which promote healthy Testosterone production in male patients.

Testosterone Production is the result of a hormone cascade which starts at the Hypothalamus, which functions as the brain’s control center. When the Hypothalamus recognizes that the body needs Testosterone, it sends a hormone to the pituitary gland known as Gonadotropin-Releasing Hormone. This hormone activates the production of two hormones both related to the healthy function of the Testes—Follicle Stimulating Hormone and Luteinizing Hormone.

These hormones pass through the bloodstream down to the testes, which then produce both Testosterone and sperm.

So Where Does Clomiphene Citrate Fit In?

Clomiphene Citrate is a pharmaceutical medication that is known as a Selective Estrogen Receptor Modulator. Remember the first step of the cascade? The Hypothalamus uses Estrogen in order to get a grip on how much Testosterone is currently circulating through the body. Adipose fat tissue has enzymes designed to convert Testosterone into Estrogen (there are other mechanisms at play as well), and when activation sites are triggered in the Hypothalamus by Estrogen, the Hypothalamus responds by reducing the level of Gonadotropin-Releasing Hormone that it releases, thereby restricting Testosterone Production.

Clomiphene Citrate bonds to these activation sites that would normally respond to Estrogen, but does not “flip the switch” that tells the hypothalamus to suppress Testosterone Precursor release, thereby increasing Testosterone Production.

Clomiphene Citrate Vs. Testosterone Therapy

Both forms of therapy are highly effective at restoring Testosterone Production, so why would someone turn to Clomiphene Citrate when they could get the real thing?

There are many patients for whom Clomiphene Citrate is the superior choice of the two options. For example, men that are interested in having children in the near future are actually doing themselves a disservice by using Testosterone. This is because Bio-Identical Testosterone actually reduces fertility for the duration of treatment, and fertility slowly returns after the therapy is suspended.

This is because when exogenous Testosterone is introduced to the body, it triggers the Hypothalamus to limit the production of Testosterone Precursors, including Luteinizing Hormone and Follicle-Stimulating Hormone. This doesn’t have a major impact on male health, because, outside of their relationship to Testosterone, both of these hormones are only really associated with fertility inside the male body.

Unfortunately, if the body is not producing enough of these two hormones, then the testes don’t get the signal to produce sperm. Sperm concentration and quality slowly declines the longer that you take Testosterone, until you are more or less infertile until you quit therapy.

Clomiphene Supports the Natural Hormone Rhythms of the Body

Clomiphene Citrate more naturally restores Testosterone Levels than Bio-Identical Testosterone, because it maintains the normal cycle of Testosterone Production. All of the hormones that your body normally produces continue being made, and you protect your fertility.

Also, many people prefer Clomiphene Citrate because it is cheaper. There are two reasons for this. First, Clomiphene is available in generic form, as many forms of Testosterone Therapy (including Testosterone Patches and Creams) are only available in patented forms.

Second, Clomiphene Citrate is less expensive because it is available in a pill form, unlike Testosterone Therapy. Bio-Identical Testosterone cannot effectively pass through the digestive system and must be delivered either by injection or via absorption.

Testosterone Therapy with HCG

Of course, there is a way to take Bio-Identical Testosterone Treatment while sustaining your fertility and natural capability to produce Testosterone. Human Chorionic Gonadotropin (HCG) is a recombinant hormone which is not produced by men, but has the ability to stimulate the production of both sperm and Testosterone by the Testes. This is because HCG is biologically and functionally similar to Luteinizing Hormone, and thus has the ability to promote fertility even though the brain is producing less of other Testosterone Precursors.

In fact, HCG is often prescribed at the end of Testosterone Therapy or between cycles in order to stimulate the Testes to return to normal function when the patient stops taking Testosterone.

Clomiphene vs. Enclomiphene

Currently, there is an alternative to Clomiphene under clinical trial known as Enclomiphene. Clomiphene is actually a combination of two Geometric Isomers, meaning that the two molecules are structurally identical, except for the rotation of their configuration. The two components of Clomiphene Citrate are Zuclomiphene and Enclomiphene.

Zuclomiphene is believed to inhibit the benefits of Enclomiphene for men slightly, and clinical research shows that Enclomiphene Citrate is moderately more effective than Clomiphene Citrate at improving male fertility and Testosterone Production. In the coming years, it is likely that Enclomiphene will be available with a prescription as a viable treatment option for Low-T and Andropause.

Clomiphene Citrate is not FDA-Approved for Testosterone Therapy

While it is true that Clomiphene has not been given the Food and Drug Administration seal of approval for Low-T, there is ample evidence, in the form of off-label prescription, that Clomiphene is a highly effective means of Testosterone Restoration. The reason why it has not been approved is more a matter of financial incentive than any potential issues with the treatment. Clomiphene has long passed into generic availability, so there is little incentive for a pharmaceutical company to pay the millions of dollars necessary to foot FDA clinical evaluation to get it approved for therapy.

Clomiphene Citrate has been used for more than fifty years, and there is a low instance of side-effects, most of which are mild. Many even consider Clomiphene to be safer than Bio-Identical Testosterone for Low-T.

Consider Your Options and Talk to Your Doctor About All of the Options Available to You as a Patient

Because of the popularity of Testosterone Therapy today, your doctor may assume that you are interested in Low-T treatment and overlook other potential options. If you are interested in Clomiphene Citrate, ask your physician about his or her opinion of the medication. If you are experiencing Fertility issues related to your Testosterone Deficiency, or if you are just looking for a safe and cost-effective form of treatment, Clomiphene Citrate may be right for you!

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