Reading Time: 3 minutesIntroduction Late-onset hypogonadism (LOH), characterized by a gradual decline in serum testosterone levels in men over 40, affects up to 30% of American males aged 50-79, according to data from the National Health and Nutrition Examination Survey (NHANES). This endocrine disorder, often termed androgen deficiency of the aging male (ADAM), manifests with symptoms including fatigue, reduced libido, and metabolic disturbances. Emerging research highlights a bidirectional relationship between LOH and liver health, where testosterone deficiency exacerbates hepatic steatosis, inflammation, and fibrosis. In the U.S., where non-alcoholic fatty liver disease (NAFLD) prevalence exceeds 30% in middle-aged men, understanding this interplay is crucial … Read more
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