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Testosterone therapy — good idea or not? – Testosterone Prescription

Written by Dr. Michael White, Published on December 6th, 2018

Unless you’ve been living in a cave, or under a rock, you’ve surely heard the term “Low-T” or seen an advertisement talking about how testosterone declines as men age and how the solution is undergoing testosterone replacement therapy (TRT). It promises an incredible allure: increased libido more muscle mass and strength, exploding energy levels to what they were in your youth, and a host of others. But is that the entire story Does it come with health risks Each birthday after 30 means a drop in testosterone levels by approximately 1%, and therefore 10% each decade. Do the math. By age 60 your testosterone levels will be about 30 percent lower than what they were when you were a young man. And, if you are able to live until age 80, you now have 50% of your youthful levels of the powerful masculine hormone. Congratulations! You’re now, in many ways, ½ a man. You’ve heard of menopause for women Andropause is what men experience…a natural, slow decline in testosterone levels. Sometimes, the decrease is fast, causing legitimate concerns. Symptoms of Low-T include hair loss, fatigue, low semen production, lowered sex drive, erectile dysfunction, hot flashes, infertility, loss of muscle and

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Testosterone shown to help sexually frustrated women- Testosterone Prescription

Written by Dr. Michael White, Published on December 6th, 2018

Several weeks ago my column, Do you want better sex? struck a resounding note not only with female readers but also with many husbands who want their wives to have fewer headaches. The general response was, Please write more about testosterone and how it can increase female libido. Testosterone, the male hormone, has been called the hormone of desire. In males the Big T builds muscle for boys and ultimately turns boys into sexually well-functioning men. Women also produce testosterone during puberty, but only about one-tenth as much as males. Later in life they produce less, and this is why some authorities believe women lose interest in sex. How do women know if they have less testosterone and therefore less tiger in the tank? Theres a good chance testosterone is lacking if they complain of little sexual desire, lack of energy, loss of height, decreased enjoyment in life, are sad or grumpy, fall asleep after meals and produce inadequate work performance. If the answer is yes to four of these conditions, there may not be enough big T. Women may lack this hormone for several reasons. In North America 700,000 hysterectomies are done every year. The ovaries that produce estrogen

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Testosterone replacement therapy improves symptoms of metabolic syndrome – Testosterone Prescription

Written by Dr. Michael White, Published on December 5th, 2018

Hormone-replacement therapy significantly improved symptoms of metabolic syndrome associated with testosterone deficiency in men, a new study from Germany finds. The results will be presented Monday at The Endocrine Society’s 94th Annual Meeting in Houston. Metabolic syndrome comprises a cluster of complications that can increase the risk of heart and blood-vessel disease as well as type 2 diabetes. These complications include excess body weight, especially around the waist and torso, and abnormal concentrations of fat in the blood, known as lipids. In particular, patients with metabolic syndrome have high blood levels of the so-called bad fats, or triglycerides and low-density lipoproteins, and insufficient amounts of the healthy fats known as high-density lipoproteins. In addition, they often have high blood pressure and sugar, or glucose, levels. Previous research has linked metabolic syndrome to testosterone deficiency, which can cause decreased muscle and bone mass, depression, low energy, and decreased sex drive and ability. In addition, testosterone deficiency is also associated with the individual symptoms of metabolic syndrome, even when they are present without the other complications. “When indicated, testosterone treatment is both essential and safe in elderly patients with symptomatic late onset hypogonadism, or testosterone deficiency,” said study lead author Aksam A.

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Acidosis: The Hidden Health Destroyer

Written by Dr. Michael White, Published on November 25th, 2018

  Acidosis: The Hidden Health Destroyer Your Most Important AND Little Known Measure of Good Health What is the most important thing you should focus on for good health?Hint: it’s not your weight…or your BMI…or your cholesterol…or your triglycerides…or even your blood pressure. Without a doubt, these numbers are important. But there is one number that tells you more than these about your health, and you need to be aware of it to ward off disease and live pain-free: Your Blood pH Level The measure of acidity or alkaline in the body is potential hydrogen, or pH, which is expressed in a number between 0 and 14, and is usually measured through blood testing. A reading of 0 is pure acid, 7 is neutral, and 14 is pure alkaline. Without exception, all of your organs, bones, tissues and joints function at their best when your blood pH is slightly alkaline, which is around 7.35. Here’s a brief look at the science behind acidosis The stomach has a normal pH measure of approximately 4.0. Consuming high pH alkaline water causes the stomach pH to rise. When the stomach pH rises above 4.5, the stomach produces more hydrochloric acid. Here is the

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Your Life on Testosterone: Overly Sure, Unwilling to Listen to Anyone

Written by Dr. Michael White, Published on July 22nd, 2018

A study testing the effect of testosterone has found that it dramatically lowers cooperation between individuals, making people more egocentric. In this study, people performed their task more poorly under the influence of testosterone. It didn’t affect their individual performance, but the lack of cooperation it caused resulted in partners making the wrong choice more frequently than they did when not under the influence of testosterone. Oh, and by the way, all the subjects were women. Self-centered, unwilling to listen, and overly sure of yourself. This is your life on testosterone, even if you are female. The study was of 17 pairs of women who had never met before. Each pair participated in two sessions held three to seven days apart. In one session, both women were given an oral testosterone supplement (80 mg of testosterone undecanoate) six to seven hours before the session. For the other session, neither woman received testosterone. Each session consisted of 192 trials. In each trial, the women sat at separate computer screens and were shown the same two sets of images. Each set contained six images of a grating. In one set, one image was sharper (higher contrast) than all the others. The women

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With testosterone, it’s ‘my way or the highway’: UK study – Testosterone Prescription

Written by Dr. Michael White, Published on February 11th, 2017

Testosterone can skew one’s judgment, creating the impression that decisions are best taken alone even in situations that call for collaboration, according to a study released Wednesday. In a clever set of experiments, scientists led by Nicholas Wright at the University of London showed that women given a dose of testosterone become less inclined to act in concert even when it was clearly in their interest to do so. Finding the right balance between working together and going solo-and knowing when to do one or the other-is an essential life skill. In some circumstances, joining forces with others is the best way to achieve a desired result: that’s why lions and hyenas hunt in packs, and why humans cooperate on the playing field, in the laboratory, or in battle. Sometimes, however, decisive individual action is needed to break free of group-think, or to come out ahead of the game. To a significant extent, our ability to navigate between these two extremes is acquired through learning and experience, but some of these impulses are hardwired too. Earlier research, for example, on the biological underpinnings of group decision making revealed that a naturally-occurring hormone, oxytocin, promotes the urge to work side-by-side. At

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Too much testosterone makes for bad decisions, tests show – Testosterone Prescription

Written by Dr. Michael White, Published on February 4th, 2017

DICK AHLSTROM, Science Editor IT CAN happen in juries and local groups, in Dáil committees and company board rooms. Too much testosterone can thwart good decision-making. People have long blamed the male hormone for damaging group dynamic and now University College London researchers have proven this to be true.   Toss in some excess testosterone and co-operation tends to go out the window. Dr Mark Wright and colleagues at the Wellcome Trust Centre for Neuroimaging at UCL tested the impact of testosterone on the levels of co-operative decision-making accomplished by groups. They publish their findings this morning in the journal Proceedings of the Royal Society B . Other experiments had already shown that subjects given the female hormone oxytocin tended to be more co-operative. The university team wanted to see whether testosterone could produce the opposite effect, Dr Wright said. Men already have high levels of the hormone and if extra is given it will quickly be broken down. For this reason only women were used as subjects, Dr Wright said. Supplements were given to elevate their testosterone levels temporarily and the women conducted a series of tests to measure levels of co-operation. Dr Wright used 17 pairs of female volunteers

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The Secret to Guys’ Sex Appeal: Low Stress, High Testosterone, Strong Immunity – Testosterone Prescription

Written by Dr. Michael White, Published on January 28th, 2017

  Washboard abs and a chiseled jaw are a draw, but a recent study suggests it may be a man’s healthy immune system that really turns women on. That makes sense, since a strong immune system signifies a healthy guy – one who’s likely to survive long enough to pass his rugged genes to the next generation. But the more surprising thing is that women can apparently spot good immunity by looking at a guy’s face. The key factor may be testosterone, the male hormone that has been associated with a man’s hardy good looks. According to a study published in the journal Nature Communications, testosterone levels are not only linked with facial attractiveness, but also with a strong immune system response. MORE: Why Fathers Have Lower Levels of Testosterone To figure out the complex relationship between hormones and hotness, researchers from Abertay University in the U.K. studied 74 Latvian men in their early 20s. They gave the men a Hepatitis B vaccine, which triggers the immune system to produce antibodies to fight the virus, and took blood samples before and after. Using the blood samples, researchers measured the men’s antibody levels, as well as levels of testosterone and the

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Testosterone, Viagra not a winning combination for erectile dysfunction – Testosterone Prescription

Written by Dr. Michael White, Published on January 21st, 2017

Using a testosterone gel in addition to Viagra doesn't make the little blue pill work any better, according to a new study.

The report's lead researcher said testosterone is typically prescribed to men who have both low testosterone levels and symptoms such as little interest in sex or low bone and muscle mass.

But, "there's a tremendous amount of clinical judgment" that goes into that, said Dr. Matthew Spitzer, from the Boston University School of Medicine. "People are certainly being prescribed and using these medications at increasing amounts."

According to Spitzer, studies have suggested that about one-quarter to one-third of men with erectile dysfunction, or ED, also have low testosterone. There's a range in part because doctors and researchers don't all agree on where the cutoff should be for low levels of the male sex hormone.

Spitzer and his colleagues found that a starting course of sildenafil citrate, marketed as Viagra, helped improve sexual functioning for men with both conditions. But adding testosterone on top of that didn't provide any added sexual benefits.

The study included 140 men, aged 40 to 70. All were prescribed Viagra at 50 or 100 milligrams, which they took as needed before sex. After three to seven weeks, half of the men were randomly assigned to also use a daily testosterone gel, Testim, and the other half used a drug-free placebo gel.

During the Viagra-only portion of the study, men's erectile function scores improved. On the sexual functioning scale, a score of 11-16 is considered "moderate" erectile dysfunction and 17-21 is "mild to moderate" dysfunction. The highest possible score, signaling no erectile problems, is a 30. On average, men's scores increased from 12.1 to 19.8 with Viagra.

The men's testosterone levels also rose on Viagra, according to the findings published Monday in the Annals of Internal Medicine.

For men who were then given the testosterone gel, testosterone levels increased significantly again. But neither those men nor the ones who used the placebo gel had any further change in their erectile function over the next three months.

There was also no difference between the two groups on measures of sexual desire, orgasm and frequency of intercourse.

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Testosterone, Viagra not a winning combination for erectile dysfunction

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Testosterone reduces group think, cooperation, and less sheep-like mentality

Written by Dr. Michael White, Published on December 24th, 2016

ScienceDaily (Jan. 31, 2012) - Testosterone makes us overvalue our own opinions at the expense of cooperation, research from the Wellcome Trust Centre for Neuroimaging at UCL (University College London) has found. The findings may have implications for how group decisions are affected by dominant individuals.

Problem solving in groups can provide benefits over individual decisions as we are able to share our information and expertise. However, there is a tension between cooperation and self-orientated behaviour: although groups might benefit from a collective intelligence, collaborating too closely can lead to an uncritical groupthink, ending in decisions that are bad for all.

Attempts to understand the biological mechanisms behind group decision making have tended to focus on the factors that promote cooperation, and research has shown that people given a boost of the hormone oxytocin tend to be cooperative. Now, in a study recently published in the journal Proceedings of the Royal Society B, researchers have shown that the hormone testosterone has the opposite effect - it makes people act less cooperatively and more egocentrically.

Dr Nick Wright and colleagues at the Wellcome Trust Centre for Neuroimaging at UCL carried out a series of tests using 17 pairs of female volunteers* who had previously never met. The test took place over two days, spaced a week apart. On one of the days, both volunteers in each pair were given a testosterone supplement; on the other day, they were given a placebo.

During the experiment, both women sat in the same room and viewed their own screen. Both individuals saw exactly the same thing. First, in each trial they were shown two images, one of which contained a high-contrast target - and their job was to decide individually which image contained the target.

If their individual choices agreed, they received feedback and moved on to the next trial. However, if they disagreed, they were asked to collaborate and discuss with their partner to reach a joint decision. One of the pair then input this joint decision.

The researchers found that, as expected, cooperation enabled the group to perform much better than the individuals alone when individuals had received only the placebo. But, when given a testosterone supplement, the benefit of cooperation was markedly reduced. In fact, higher levels of testosterone were associated with individuals behaving egocentrically and deciding in favour of their own selection over their partner's.

"When we are making decisions in groups, we tread a fine line between cooperation and self-interest: too much cooperation and we may never get our way, but if we are too self-orientated, we are likely to ignore people who have real insight," explains Dr Wright.

"Our behaviour seems to be moderated by our hormones - we already know that oxytocin can make us more cooperative, but if this were the only hormone acting on our decision-making in groups, this would make our decisions very skewed. We have shown that, in fact, testosterone also affects our decisions, by making us more egotistical.

"Most of the time, this allows us to seek the best solution to a problem, but sometimes, too much testosterone can help blind us to other people's views. This can be very significant when we are talking about a dominant individual trying to assert his or her opinion in, say, a jury."

Testosterone is implicated in a variety of social behaviours. For example, in chimpanzees, levels of testosterone rise ahead of a confrontation or a fight. In female prisoners, studies have found that higher levels of testosterone correlate with increased antisocial behaviour and higher aggression. Researchers believe that such findings reflect a more general role for testosterone in increasing the motivation to dominate others and increase egocentricity.

Commenting on the findings, Dr John Williams, Head of Neuroscience and Mental Health at the Trust, said: "Cooperating with others has obvious advantages for sharing skills and experience, but we know it doesn't always work, particularly if one alpha male or alpha female dominates the decision making. This result helps us understand at a hormonal level the factors that can disrupt our attempts to work together."

The Wellcome Trust funded this study.

*Testosterone is naturally secreted in men and women, and testosterone levels are correlated with important behaviours (e.g. antisocial behaviour) in both men and women. For the size of dose given experimentally, in women this markedly increases their testosterone from its low baseline level. In men, however, the situation is more complicated: men already have high baseline levels of testosterone, so giving such doses will decrease their own production of testosterone, a feedback effect that will act to offset the increase caused by the treatment itself. The researchers therefore used female subjects because giving standard experimental doses causes a straightforward and well-characterised increase in their testosterone levels.

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The above story is reprinted from materials provided by Wellcome Trust.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Wright ND et al. Testosterone disrupts human collaboration by increasing egocentric choices. Proc Roy Soc B, 2012

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Testosterone makes us less cooperative and more egocentric

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