Enclomiphene Citrate (Androxal) for Low-T and Infertility

Posted by Dr. Michael White, Updated on May 22nd, 2020
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While testosterone therapy is a fantastic tool in the arsenal against low-T and andropause, there are other options available for testosterone replacement. One group for whom testosterone therapy is particularly problematic is men that are looking to conceive.

Bio-identical testosterone effectively takes over for almost every aspect of natural testosterone production. Unfortunately, however, testosterone therapy temporarily suppresses fertility for the duration of the treatment. This inevitably leads men with fertility-needs to seek other treatment.


Why Does Testosterone Therapy Lead to Temporary Infertility?

In a closed system, the body produces testosterone when the hypothalamus receives input to produce more testosterone. The brain monitors circulating testosterone levels and responds accordingly. In the case of testosterone hormone therapy, the hypothalamus gets the signal to limit or stop testosterone production based on biological feedback.

In the process of this hormonal cascade, the pituitary limits or halts production of vital testosterone precursors, including luteinizing hormone and follicle-stimulating hormone. Both hormones are critical for the production of healthy sperm. This is why testosterone treatment negatively affects fertility, while preserving most other testosterone benefits.

Enclomiphene Citrate (Androxal) Boosts Testosterone and Encourages Fertility

For patients that are interested in maintaining fertility while also promoting optimal testosterone levels, Enclomiphene Citrate has shown to be an effective hormone replacement therapy option. Numerous studies have shown that Enclomiphene Citrate (Androxal) is capable of boosting testosterone levels into the normal and healthy range for patients with low-T. The considerable advantage of Enclomiphene Citrate over traditional testosterone therapy is that it supports adequate sperm production for fertilization. If you're interested in having a child, testosterone therapy is simply not an option.

A secondary advantage of Enclomiphene Citrate is that Enclomiphene Citrate is prescribed as a daily pill, bypassing the hassle of testosterone injections and creams. While the latest testosterone pills (such as Jatenzo) are safe and available, Enclomiphene Citrate (Androxal) may be more affordable for your individual use, even if you aren't interested in the fertility-boosting ability of Enclomiphene Citrate. In the case that you consider reduced fertility a benefit rather than a drawback, Enclomiphene Citrate is likely not for you.

What is Enclomiphene Citrate (Androxal), and How Does it Work?

Enclomiphene Citrate is related to Clomid (Clomiphene Citrate), which is primarily used to stimulate ovulation in women. Clomid has been used off-label for men with low-T but has never been indicated for use in men.

Enclomiphene Citrate is a similar medication but is particularly tuned to maximize the benefits of Clomid while mitigating the side-effects associated with its formulation. Repros Therapeutrics attempted to achieve FDA-approval for Androxal Enclomiphene Citrate but abandoned the project in spite of promising results. Enclomiphene Citrate is still widely available across the country, however.

Enclomiphene Citrate boosts testosterone because it works as an estrogen blocker on the male pituitary gland. With the influence of estrogen on the pituitary gland muted, the organ can respond more actively to low-T conditions. The end result is an increase in luteinizing hormone and follicle-stimulating hormone levels. This boosts sperm count, increases fertility, and provides all the other benefits of traditional testosterone treatment.

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