Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.
Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor.
During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).
There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.
Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, testosterone cypionate can be given at intervals of two to four weeks.
Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.
About 90 percent of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the conjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways.
The half-life of testosterone cypionate when injected intramuscularly is approximately eight days.
In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.
Originally posted here:
DailyMed - TESTOSTERONE CYPIONATE- testosterone cypionate ...
- Testosterone Cypionate Method - January 17th, 2022
- Testosterone Cypionate | Steroidology.com - May 25th, 2021
- Testosterone Cypionate Injectable - April 7th, 2020
- Testosterone cypionate: Indications, Side Effects, Warnings - Drugs.com - August 14th, 2016
- Testosterone cypionate - about Anabolic Steroids - June 23rd, 2016
- Testosterone Cypionate Cycle - Testosterone Cypionate .com - June 23rd, 2016
- Benefits of Testosterone Cypionate - Testosterone ... - June 16th, 2016
- Testosterone Cypionate Injection, USP - DailyMed - May 22nd, 2016
- Depo-Testosterone (Testosterone Cypionate Injection) - RxList - May 6th, 2016
- DailyMed - DEPO-TESTOSTERONE- testosterone cypionate injection, solution - May 2nd, 2016
- Testosterone Cypionate - Steroids for Sale | Buy ... - May 1st, 2016
- About Testosterone Cypionate Injections | Anti-Aging Group - April 26th, 2016
- testosterone cypionate intramuscular : Uses, Side Effects, Interactions ... - April 13th, 2016
- TESTOSTERONE CYPIONATE- testosterone cypionate injection - DailyMed - April 13th, 2016
- Side Effects of Testosterone Cypionate | eHow - February 8th, 2016
- Testosterone Cypionate Male Enhancement Information - December 21st, 2015
- Testosterone Cypionate - 200mg/ml 10ml/vial EP - PSL - August 29th, 2015
- Testosterone Cypionate - buy Testosterone Cypionate ... - August 29th, 2015
- Testosterone - Testosterones.Com - August 29th, 2015
- Testosterone Cypionate 200mg per ml - LA Pharma - Injectible ... - August 29th, 2015
- DailyMed - DEPO-TESTOSTERONE- testosterone cypionate ... - August 11th, 2015
- DailyMed - TESTOSTERONE CYPIONATE- testosterone cypionate injection ... - July 19th, 2015
- Depo-Testosterone (Testosterone Cypionate Injection) Drug ... - July 3rd, 2015
- Testosterone Cypionate for Sale: Injectable Testosterone ... - May 26th, 2015
- Buy TESTOSTERONE STEROIDS: Testosterone Cypionate - May 23rd, 2015
- Testosterone Cypionate Injections for Sale - Best Price on ... - April 4th, 2015
- TESTOSTERONE CYPIONATE | XRoids.com - March 17th, 2015
- Depot Testosterone (Testosterone Cypionate) - March 6th, 2015
- Testosterone Cypionate - Growth hormone - March 5th, 2015
- Welcome to Testosterone Cypionate A Potent Androgen - February 18th, 2015
- Testosterone Cypionate A Potent Long-Acting Androgenic Anabolic ... - February 18th, 2015
- Genuine Cheap Testosterone Cypionate for Sale Online - January 20th, 2015
- Anabolic Steroids List: Benefits of Testosterone Cypionate - September 17th, 2014
- testosterone cypionate intramuscular : Uses, Side Effects ... - September 1st, 2014
- Derivatives Of Testosterone - What does Testosterone Cypionate do - Video - August 30th, 2014
- Derivatives Of Testosterone - Testosterone Cypionate dosage and side effects - Video - August 30th, 2014
- Testosterone Cypionate A Gentle Way to Elevate ... - May 8th, 2014
- TestosteroneCypionat - TOMA Ardream warrior - priest ANATOLIA - GiYOTiN Clan - Video - May 6th, 2014
- Testosterone Cypionate - FDA prescribing information, side ... - May 2nd, 2014
- Testosterone Cypionate - Roid-Shop.com - April 30th, 2014
- Buy Testosterone Cypionate Injection Online | steroid ... - April 15th, 2014
- Testosterone Cypionate - Steroids Profile - March 11th, 2014
- Testosterone Cypionate - Steroidology.com | Uncover the ... - January 27th, 2014
- Testosterone cypionate: Indications, Side Effects ... - January 20th, 2014
- Testosterone Cypionate for Muscle Building | eHow - December 30th, 2013
- Testosterone Cypionate - Steroid .com - December 21st, 2013
- Testosterone Cypionate Injection, USP100 mg/mL and 200 mg/mL - December 6th, 2013
- Testosterone Cypionate – A Gentle Way to Elevate ... - November 23rd, 2013
- Testosterone Cypionate Official FDA information, side effects ... - November 17th, 2013
- Testosterone Cypionate - Testosterone Injections ... - November 16th, 2013
- Testosterone cypionate: Indications, Side Effects, Warnings ... - November 10th, 2013
- Testosterone Cypionate - Steroidology.com | Uncover the truth ... - November 10th, 2013
- Testosterone Cypionate Official FDA information, side effects and ... - November 6th, 2013
- Testosterone Cypionate - Steroid .com - Anabolic Steroids ... - November 6th, 2013
- testosterone cypionate IM : Uses, Side Effects, Interactions ... - November 3rd, 2013
- Testosterone Cypionate - Testosterone Injections | Testosterone ... - October 31st, 2013
- Testosterone Cypionate and Testosterone Enanthate Information - October 31st, 2013
- Testosterone Cypionate - Testosterone Cypionate .com - October 31st, 2013
- Subcutaneous Testosterone Cypionate Injection - Video - August 22nd, 2013
- will testosterone cypionate build muscle | Pro Testosterone - July 30th, 2013
- Testosterone Cypionate Advantages And Disadvantages » I Click U ... - July 25th, 2013
- Testosterone Cypionate And Its Use In Sports » I Click U Click ... - July 23rd, 2013
- Compared – Essential Details In testosterone cypionate | Health ... - May 17th, 2013
- Welcome to autumnhorne Testosterone Cypionate A Potent Long ... - February 19th, 2013
- Tesosterone - Injectible or Gel? - August 10th, 2011
Word Count: 441