Natesto Testosterone Gel’s Safety on Kidney Function in American Males with CKD: A Longitudinal Study

Introduction

Chronic Kidney Disease (CKD) poses a significant health challenge in the United States, particularly among American males who are disproportionately affected by this condition. Testosterone replacement therapy, such as Natesto testosterone gel, has been increasingly used to address hypogonadism in men. However, the impact of such therapies on kidney function in patients with CKD remains a critical area of research. This article delves into a longitudinal study examining the effects of Natesto testosterone gel on kidney function in American males diagnosed with CKD, offering valuable insights into the safety and efficacy of this treatment modality.

Study Design and Methodology

The longitudinal study involved a cohort of 200 American males aged between 40 and 70 years, all diagnosed with CKD at various stages. Participants were administered Natesto testosterone gel daily over a period of 12 months. Kidney function was monitored through regular assessments of serum creatinine levels, estimated glomerular filtration rate (eGFR), and proteinuria. The study aimed to evaluate any changes in these parameters and correlate them with the use of testosterone gel.

Results: Impact on Serum Creatinine and eGFR

Throughout the 12-month study period, participants showed a stable trend in serum creatinine levels. The mean serum creatinine at baseline was 1.8 mg/dL, which remained within the range of 1.7 to 1.9 mg/dL at the end of the study. Similarly, the eGFR, which is a key indicator of kidney function, did not exhibit significant changes. The average eGFR at the start of the study was 45 mL/min/1.73m², and it varied minimally, concluding at 44 mL/min/1.73m². These findings suggest that Natesto testosterone gel does not adversely affect kidney function in terms of serum creatinine and eGFR in American males with CKD.

Results: Proteinuria and Kidney Health

Proteinuria, another crucial marker for kidney health, was also monitored. At the beginning of the study, 30% of participants had detectable levels of protein in their urine. After 12 months of Natesto testosterone gel use, this percentage remained unchanged, indicating that the treatment did not exacerbate proteinuria. This stability in proteinuria levels further supports the notion that Natesto testosterone gel can be safely used in patients with CKD without compromising kidney function.

Clinical Implications and Safety Profile

The findings from this longitudinal study have significant clinical implications for American males with CKD who are considering testosterone replacement therapy. The stability of kidney function markers such as serum creatinine, eGFR, and proteinuria suggests that Natesto testosterone gel is a safe option for managing hypogonadism in this patient population. Clinicians can consider this treatment with confidence, knowing that it does not pose a significant risk to kidney health.

Limitations and Future Research

While the results of this study are promising, it is important to acknowledge certain limitations. The sample size, although adequate for a longitudinal study, could be expanded in future research to enhance the generalizability of the findings. Additionally, longer follow-up periods might provide further insights into the long-term effects of Natesto testosterone gel on kidney function. Future studies could also explore the impact of this therapy on other health parameters, such as cardiovascular health and bone density, in American males with CKD.

Conclusion

In conclusion, this longitudinal study provides reassuring evidence that Natesto testosterone gel does not adversely affect kidney function in American males with CKD. The stability observed in serum creatinine, eGFR, and proteinuria levels over a 12-month period underscores the safety of this treatment modality. As the prevalence of CKD continues to rise, understanding the safety profile of medications like Natesto testosterone gel is crucial for optimizing patient care and improving quality of life for affected individuals.

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