Decline in testosterone level could trigger Parkinson's disease

Recommended by Dr. Michael White, Updated on January 5th, 2018

Washington, July 27 (ANI): A sudden decrease of testosterone, the male sex hormone, may cause Parkinson's like symptoms in male mice, a new study has found.

One of the major roadblocks for discovering drugs against Parkinson's disease is the unavailability of a reliable animal model for this disease.

"While scientists use different toxins and a number of complex genetic approaches to model Parkinson's disease in mice, we have found that the sudden drop in the levels of testosterone following castration is sufficient to cause persistent Parkinson's like pathology and symptoms in male mice," Dr. Kalipada Pahan, lead author of the study and the Floyd A. Davis endowed professor of neurology at Rush University Medical Center, said.

"We found that the supplementation of testosterone in the form of 5-alpha dihydrotestosterone (DHT) pellets reverses Parkinson's pathology in male mice," the researcher said.

"In men, testosterone levels are intimately coupled to many disease processes," Pahan said.

Typically, in healthy males, testosterone level is the maximum in the mid-30s, which then drop about one percent each year.

However, testosterone levels may dip drastically due to stress or sudden turn of other life events, which may make somebody more vulnerable to Parkinson's disease.

"Therefore, preservation of testosterone in males may be an important step to become resistant to Parkinson's disease," Pahan added.

The findings are published in the Journal of Biological Chemistry. (ANI)

Read more:

Decline in testosterone level could trigger Parkinson's disease

Contact Us Now

Your Name (*)
Your Email (*)
Your Phone (*)
Select A Program
Select Your US State (*)
Select your age (30+ only)
Confirm over 30 years old (*) Yes
Confirm United States Resident? (*) Yes
(*) - Required
After completing the contact form above, press the submit button. We will send you a confirmation email. Please check your email. For security purposes, please give us a call at 1-800-469-3343 if you don't receive an email.

Related Post

Word Count: 239

Comments are closed.


specialist low

testosterone chart low t commercial

how to increase free levels