Low T’ treatment appears to be safe for men with heart Disease.

Posted by Brianna Clark, Updated on October 9th, 2023
Reading Time: 4 minutes

Testosterone, a hormone primarily associated with male characteristics, has long been a subject of controversy regarding its effects on cardiovascular health. While there has been concern that testosterone replacement therapy (TRT) might be detrimental to individuals with heart disease, recent research suggests that low testosterone (Low T) treatment appears to be safe for men with underlying cardiac conditions. Our comprehensive review suggests that the best low t treatment is generally safe for men with heart disease, and its benefits may outweigh potential risks. This article reviews the current literature on the relationship between testosterone and heart health, with a focus on the safety and efficacy of Low T treatment in men with heart disease.


Testosterone is a crucial hormone in the male body, responsible for the development of secondary sexual characteristics and regulating various physiological processes. Its levels tend to decline with age, leading to a condition known as Low T or hypogonadism. Low T is associated with a range of symptoms, including fatigue, reduced muscle mass, decreased libido, and mood disturbances. To address these issues, testosterone replacement therapy (TRT) has become a common treatment option.

However, concerns have been raised over the potential risks of TRT, particularly in men with preexisting heart disease. Some studies have suggested a possible link between elevated testosterone levels and an increased risk of cardiovascular events. This has led to a debate over the safety of Low T treatment in individuals with heart conditions.

In this article, we aim to review the current evidence on the relationship to assess if testosterone bad for heart and examine whether Low T treatment is safe for men with heart disease.

Testosterone and Heart Health: The Controversy

Testosterone, a hormone primarily associated with male sexual characteristics, also plays a role in cardiovascular health. Several studies have suggested that low testosterone levels may be associated with an increased risk of cardiovascular disease (CVD). However, the relationship between testosterone and heart health is complex and not fully understood. It remains unclear whether low T is a cause or a consequence of heart disease -moreover, if low t treatment for men is safe or not.

The most common cause of mortality in the world is cardiovascular disease (CVD). Numerous variables, such as diabetes, obesity, hypertension, dyslipidemia, and advancing age, raise the risk of CVD. Men are more likely than women to develop cardiovascular disease (CVD), and there is evidence that sex hormones may play a role in both men's and women's CVD etiology. While estrogen has a well-known preventive effect on cardiovascular health, the impact of testosterone is less certain.

Initially, it was thought that testosterone bad for heart because of an increased incidence of early cardiovascular events in males. This finding has been corroborated by several sizable observational and randomized studies, although testosterone may also play a cardioprotective effect, according to other research.

The association between testosterone and cardiovascular risk and illness has to be better understood to influence guidelines for using these therapies, as testosterone therapies are utilized in the treatment of problems that impact millions of men worldwide.

According to the Massachusetts Male Aging Study, testosterone levels peak at the age of 30 and thereafter fall by 1% to 2% per year. This finding sparked curiosity about the relationship between low testosterone levels and cardiovascular risk. Years of observational research and reviews have been conducted due to speculation about the hormone's effects.

Numerous population-based studies have discovered an antagonistic relationship between endogenous testosterone levels and cardiovascular and all-cause mortality, particularly in older men. A senior men's prospective research indicated that men in the lowest quartile of total testosterone levels had 40% greater odds of dying within 20 years compared to those in the upper quartile, which was not explained by a variety of comorbidities and risk factors, including age. An 8-year prospective cohort study of male veterans supported these findings. The study also linked higher cardiovascular mortality to lower testosterone levels. The prospective Rotterdam trial found an inverse relationship between testosterone levels in older men and the risk and development of severe aortic atherosclerosis, and these findings are in line with those findings. [1]

Assessing the Safety of Testosterone Therapy: A Comprehensive Review

Is low t treatment safe?

To get their levels of the male hormone back to normal, millions of American men take prescription testosterone injections or gels (commonly referred to as TRT treatment). The continuous pharmaceutical marketing blitz claims that low t treatment for men may improve a man's mental, physical, and sexual functioning. However, valid safety worries continue. For instance, elderly men using testosterone replacement medication may be at increased risk for cardiac events.

Only a tiny percentage of men who receive the best low t treatment have acute adverse effects such as acne, sleep apnea, swollen or painful breasts, or ankle edema. The danger of clotting may be increased by high red blood cell counts, which is another concern for doctors.

Long-term testosterone treatment users tend to be more susceptible to cardiovascular issues such as heart attacks, strokes, and heart disease-related fatalities. For instance, when preliminary findings suggested that men receiving testosterone replacement medication had much higher cardiac issues, researchers stopped the Testosterone in Older Men trial.

If you have heart disease, have experienced a heart attack, are at high risk for developing prostate cancer, have severe urinary symptoms as a result of prostate enlargement, or have several risk factors for heart issues, you should proceed with testosterone therapy with care. [2]


The safety of testosterone replacement therapy for men with heart disease remains a subject of ongoing research and debate. While concerns have been raised, the current evidence suggests that low T treatment appears to be safe when administered under appropriate medical supervision. Some studies even suggest potential cardiovascular benefits for certain individuals.

Men with heart disease and low testosterone need to work closely with their healthcare providers to make informed decisions about TRT. Individual risk factors, treatment options, and regular monitoring should be considered to ensure the best possible outcomes for each patient.

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