[Editors Note: Some studies indicate Testosterone can increase the risk of cardiovascular disease, stroke, and heart attack, while some studies indicate the opposite might be the case. The article below takes the position Testosterone therapy may help men with a risk of heart failure and is safe for the heart. Be aware of the risks, benefits, effects, dangers, positive, negative, and side effects of Testosterone therapy before starting.]
Testosterone Therapy May Help Men With Heart Failure
MONDAY, Aug. 24 (HealthDay News) — Injections of the male hormone testosterone increased blood-pumping ability and heart muscle strength in men with risk of heart failure, Italian researchers report.
“From our study, it appears that testosterone supplementation is useful for both patients with low and normal testosterone levels, although the improvements are greater in those with low levels,” said Dr. Ferdinando Iellamo, an assistant professor of internal medicine at the University of Rome Tor Vergata, and lead author of a report in the Sept. 1 issue of the Journal of the American College of Cardiology.
The use of testosterone for heart failure, or the progressive loss of the ability to pump blood throughout the body, has been controversial in some cases.
About one in every four men with chronic heart failure has evidence of testosterone deficiency because the production of the hormone declines with age. Few studies of testosterone therapy and heart failure have been done in the United States, but several have been reported in Europe.
Elderly Men with Heart Failure and Testosterone Treatment Study
The Italian study included 70 elderly men with heart failure, all of whom had low testosterone levels. All received standard heart failure therapy, but half also received injections of 1,000 milligrams of long-acting testosterone at the start, and again at six and 12 weeks.
A series of examinations — electrocardiograms, exercise tests, and assessments of muscle strength — showed improvements in the men who received the hormone treatment but not in those who didn’t.
It’s not possible to specify the timing and dosage of testosterone therapy for men with heart failure, Iellamo said.
“There is no current guideline,” he said. “However, our study indicates that long-acting testosterone at the dose and intervals we employed [to date used only in patients with hypogonadism] is safe and well-tolerated in patients with heart failure.”
"The study was not designed to determine whether testosterone therapy would prolong survival of men with heart failure," Iellamo said. “Future large trials are needed to appropriately evaluate the outcome."
Such a multi-center trial is in the early planning stage, Iellamo noted. Meanwhile, his group is studying the effects of testosterone therapy in women. “Preliminary results seem promising,” he added.
Women are also prone to low testosterone as they age, especially after menopause, and it can cause issues with libido and pain during sex.
Only Use Testosterone under a Doctor-Mediated Program
Men with heart failure who are tempted to try testosterone therapy on their own should avoid the temptation, he said.
“It is absolutely contraindicated that patients choose testosterone, as well as all drugs, on their own,” Iellamo said.
The warning is especially important for men with high levels of prostate-specific antigen, an indicator of prostate cancer risk, he noted.
“This study confirms our previous finding for a beneficial effect of testosterone in men with moderate chronic heart failure, improving functional exercise capacity and insulin resistance,” said Dr. T. Hugh Jones, a consultant endocrinologist at the University of Sheffield in England.
Positive Results Treating Heart Failure with TRT
Jones and his colleagues have reported two studies with positive results, one using testosterone injections, the other using a hormone-delivering skin patch.
“Historically, testosterone-replacement therapy has been contraindicated in men with chronic heart failure,” Jones said. “This was due to the fluid retention observed with older forms of testosterone preparation. This study, along with our studies, show that testosterone is safe in these patients and has a benefit on the underlying condition.”
But the case for testosterone therapy in heart failure is far from proven, he said. “Now, longer-term studies evaluating effects on survival, quality of life, and longer-term safety need to be done to establish if this treatment should be used routinely in the treatment of heart failure in men,” Jones said.
Heart failure and its treatment are described by the U.S. National Library of Medicine.
By E. Edelson
SOURCES: Ferdinando Iellamo, M.D., assistant professor, internal medicine, University of Rome Tor Vergata; T. Hugh Jones, M.D., consultant endocrinologist, University of Sheffield, England; Sept. 1, 2009, Journal of the American College of Cardiology
Last Updated: Aug. 24, 2009
- Testosterone Injection Replacement Therapy for Low-T - November 17th, 2020
- Treatment for male menopause - October 19th, 2020
- Learning About Testosterone: Testosterone Esters - August 13th, 2020
- Testosterone Replacement Beneficial for Modern Men? - February 11th, 2020
- Testosterone Injections For Women: Benefits & Side Effects - May 4th, 2016
- Testosterone Injections - Testosterone Injections for Men - April 30th, 2016
- Treatment for Hypogonadism with Testosterone Injections - October 21st, 2015
- Risk of Testosterone Injections | eHow - October 14th, 2015
- Testosterone Injections - Elite Men's Guide - September 11th, 2015
- Testosterone Injections for Men - Men's Hormonal Health - August 23rd, 2015
- testosterone injections withdrawal - Men's Health - MedHelp - May 28th, 2015
- LowTestosterone.com - Proper Injection and Dosing ... - May 13th, 2015
- Happy Mondays Star Shaun Ryder Needs Testosterone Injections To Stay Alive - April 9th, 2015
- Testosterone Injection - SteroidAbuse .com - March 23rd, 2015
- Male Testosterone Therapy - Renew Man - February 23rd, 2015
- TESTOSTERONE | Testosterone Injections | Testosterone ... - February 23rd, 2015
- side effects of testosterone injections - Video - January 11th, 2015
- All about Testosterone Injections - 2014's Best 3 ... - December 2nd, 2014
- Testosterone Injections Side Effects & Benefits - October 28th, 2014
- MegaTEST 500 - Video - September 13th, 2014
- Shot Day For Me! - Video - July 13th, 2014
- Testosterone Injections | Get Low Testosterone Therapy at ... - April 30th, 2014
- Testosterone Injections: Uses, Side Effects & Warnings ... - April 18th, 2014
- Growing pains on testosterone with fibromyalgia. - Video - April 17th, 2014
- Testosterone Injections for Men | eHow eHow | How to - April 14th, 2014
- Testosterone Injections for Women - Buzzle - January 30th, 2014
- Testosterone Injections for Men | eHow - eHow | How to ... - January 24th, 2014
- Kindergartner gets no money for lost testicles - January 24th, 2014
- Boy who lost testicles during OHSU surgery awarded no money by Portland jury - January 24th, 2014
- Medical board charges Modesto doctor with negligence in weight-loss program - January 23rd, 2014
- Testosterone Injections for Men - Shots, Side Effects ... - January 19th, 2014
- When You Inject Testosterone Be Aware Of The Possible Mood Swing Side Effects - January 9th, 2014
- Side Effects of Testosterone Injections | eHow - December 24th, 2013
- Testosterone Injections - Steroid .com - December 19th, 2013
- Testosterone Injections for Low Testostosterone Treatment ... - November 19th, 2013
- Testosterone Replacement Therapy: Testosterone Injections ... - November 19th, 2013
- How Intramuscular Testosterone Injections is Done? - Video - November 14th, 2013
- Testosterone Injections for Low Testostosterone Treatment @ www ... - November 2nd, 2013
- Testosterone Injections - Testosterone Injections for Men and Women - October 31st, 2013
- Testosterone Injections - Steroid .com - Anabolic Steroids ... - October 31st, 2013
- Testosterone Injections for Men | eHow - eHow | How to Videos ... - October 31st, 2013
- Testosterone Injections for Men - Shots, Side Effects, Dosage ... - October 31st, 2013
- Testosterone Injections Side Effects - Buzzle - October 31st, 2013
- What Are Testosterone Injections? - Video - January 18th, 2013
- the truth about 6 pack abs amazon - Video - December 10th, 2012
- the truth about 6 pack abs ebook - Video - December 10th, 2012
- Free 6 pack abs exercises - Video - December 10th, 2012
- Free free lower ab workouts muscles - Video - December 10th, 2012
- Free abs circle pro workout - Video - December 10th, 2012
- Free truth about 6 pack abs - Video - December 10th, 2012
- Testosterone Injections: How To Inject Testosterone - Low Testosterone Treatment - Video - November 2nd, 2012
- Military press 90lb dumbbells 40 years old - Video - November 2nd, 2012
- Testosterone Roundtable -- Low Testosterone Treatment Options (Part 5) - Video - November 2nd, 2012
- Wall Street’s Castration Not Just Metaphorical - February 14th, 2012
Word Count: 762