Category Archives: Hypogonadism

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If you have signs and symptoms of low testosterone that bother you or effect the quality of your living condition (quality of life), there are many choices for raising testosterone levels. Not everyone chooses treatment. Testosterone replacement therapy (TRT) can be given using: Buy Testosterone Gel or Cream The most common type is skin gel or creams, which is used by about 50 out of 100 patients. The gel or cream is rubbed onto your shoulders or upper arms after a shower. Buy Testosterone Shots About 25 out of 100 patients use testosterone shots to treat testosterone deficiency. Testosterone Patches in Decline of Use Less than 5 to 10 out of 100 use testosterone patches, and the number is declining rapidly. Testosterone Pellets Nearly three out of 100 patients use testosterone in other forms, such as pellets placed in the body. Pellets are usually placed under the skin near the belly region and slowly release the Testosterone over an extended period of time. Testosterone Pills Are Not Recommended At this time, pills are not approved for use in the U.S. When You Should Take Testosterone? You should not take testosterone for non-medical reasons, such as bodybuilding, preventing aging changes or … Read more »

Testosterone deficiency is frequently seen in both men and women with HIV. Endocrine abnormalities, which can affect testosterone production, have long been recognized as a complication of HIV since the earliest days of the pandemic (although it has generally been associated with late stage disease). However, recent research has shown that nearly one out of every five men with HIV has documented testosterone deficiency, irrespective of CD4 count, viral load, or treatment status. Similarly, testosterone deficiency is seen in one in four HIV-positive women, most often in the context of severe, unexplained weight loss (HIV wasting). Testosterone is the steroid hormone which is central to the development of the testes (testicles) and prostate in men as well as the promotion of secondary male sexual characteristics (e.g., lean muscle mass, bone mass, hair growth). Testosterone is also important to women in maintaining normal muscle and bone mass, although at levels around 10% less than men. In both men and women, testosterone is essential to a person's overall health and well-being, contributing to an individual's strength, energy levels, and libido. By contrast, testosterone depletion is associated with: Testosterone deficiency in men with HIV is largely associated with an endocrine abnormality called male … Read more »

Definition Hypogonadism occurs when the body's sex glands produce little or no hormones. In men, these glands (gonads) are the testes. In women, these glands are the ovaries. Gonadal deficiency The cause of hypogonadism can be primary or central. In primary hypogonadism, the ovaries or testes themselves do not function properly. Causes of primary hypogonadism include: The most common genetic disorders that cause primary hypogonadism are Turner syndrome (in women) and Klinefelter syndrome (in men). If you already have other autoimmune disorders you may be at higher risk of autoimmune damage to the gonads. These can include disorders that affect the liver and adrenal and thyroid glands as well as type 1 diabetes. In central hypogonadism, the centers in the brain that control the gonads (hypothalamus and pituitary) do not function properly. Causes of central hypogonadism include: A genetic cause of central hypogonadism is Kallmann syndrome. Many people with this condition also have a decreased sense of smell. Girls who have hypogonadism will not begin menstruating. Hypogonadism can affect their breast development and height. If hypogonadism occurs after puberty, symptoms in women include: In boys, hypogonadism affects muscle, beard, genital and voice development. It also leads to growth problems. In … Read more »

Hypogonadism is a medical term for a defect of the reproductive system which results in lack of function of the gonads (ovaries or testes). Hypogonadism may occur if the hypothalamic-pituitary-gonadal axis is interrupted at any level. Hypergonadotropic hypogonadism (primary hypogonadism) results if the gonad does not produce the amount of steroid sufficient to suppress secretion of LH and FSH at normal levels. Hypogonadism resulting from defects of the gonads is traditionally referred to as primary hypogonadism. Examples include Klinefelter syndrome and Turner syndrome. Hypogonadism resulting from hypothalamic or pituitary defects are termed secondary hypogonadism or central hypogonadism (referring to the central nervous system). Hypogonadism can affect men of any age, from fetal development, through puberty and adulthood. Hypogonadism is one of the main causes of male infertility. It is estimated that 13 million men in the United States alone are affected by hypogonadism. Hypogonadism is caused by deficient testosterone secretion by the testes. The two basic types of male hypogonadism are Primary and Secondary. Hypogonadism Primary, also known as primary testicular failure, originates from an abnormality in the testicles. Hypogonadism may be induced by chronic use of anabolic/androgenic steroids (AAS). The Secondary type of hypogonadism is caused by defects in … Read more »

Testosterone levels in men decline with age, at a rate of about 1% per year beginning at about 40 years old.3 Epidemiological studies have determined that total testosterone follows an age-related decline with mean serum concentration at the age of 75 years approximately two thirds that at 25 years.4 According to reports, approximately 74% of chronic opioid users5, 50% of AIDS patients6, 52% of obese men7, 50% of diabetic men7,8 have low testosterone. Other causes of lowered testosterone levels include: injury, infection, or loss of the testicles; chemotherapyor radiation treatment for cancer; genetic abnormalities such as Klinefelter's Syndrome (extra X chromosome); hemochromatosis(too much iron in the body); dysfunction of the pituitary gland; inflammatory diseases such as sarcoidosis (a condition that causes inflammation of the lungs); chronic illness; chronic kidney failure; liver cirrhosis; stress; and, alcoholism. 3Feldman HA, et al. J. Clin Endocrinol Metab 2002; 87 (2):589-98 4Myers et al. Rev Urol 2003; 5 (4) 216-226 5Daniell HW., J Pain. 2002; 3:377-384 6Dobs AS. Baillires Clin Endocrinol Metab. 1998; 12:379-390 7Mulligan T, et al. Int J Clin Pract. 2006;60:762-769 8Bodie J, et al. J Urol. 2003;169:22622264 9Jackson JA et al., AM. J. Med. Sci. 1992,304 (1) 4-8 Originally posted here: Lipocine … Read more »

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Early symptoms of low testosterone in men include low libido (sex drive). As levels become very low, sexual dysfunction (also called "erectile dysfunction (ED)" or "impotence") often develops. Other signs and symptoms of low testosterone may include depression, fatigue, osteoporosis, loss of muscle mass, an increase in abdominal fat, development of breast tissue (gynecomastia) and infertility. Symptoms of low testosterone in women may include low libido (sex drive), sexual dysfunction, fatigue, loss of muscle mass, an increase in body fat and bone loss. Pituitary Symptoms There are many causes of low testosterone. These can be differentiated with hormone testing. Pituitary dysfunction is one cause of low testosterone and can result from compression of the pituitary gland by a large pituitary tumor. In addition, excess hormone secretion by a pituitary tumor can cause low testosterone either directly or indirectly. For example, elevated prolactin, cortisol or GH levels can cause low testosterone. Testosterone levels normalize with treatment of the tumor in some, but not all, cases. There are other causes of low testosterone that are not related to pituitary tumors. These include anabolic steroid use (for body building or athletic enhancement), obesity, depression, and testicular failure. Research Studies The complications of low … Read more »

By Irvin H. Hirsch, MD NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version NOTE: This is the Professional Version. DOCTORS: Click here for the Consumer Version Hypogonadism is defined as testosterone deficiency with associated symptoms or signs, deficiency of spermatozoa production, or both. It may result from a disorder of the testes (primary hypogonadism) or of the hypothalamic-pituitary axis (secondary hypogonadism). Both may be congenital or acquired as the result of aging, disease, drugs, or other factors. Additionally, a number of congenital enzyme deficiencies cause varying degrees of target organ androgen resistance. Diagnosis is confirmed by hormone levels. Treatment varies with etiology but typically includes gonadotropin-releasing hormone, gonadotropin, or testosterone replacement. DELATESTRYL No US brand name ZOLADEX ALDACTONE REGLAN TAGAMET NIZORAL LUPRON OZURDEX NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version NOTE: This is the Professional Version. DOCTORS: Click here for the Consumer Version Excerpt from: Male Hypogonadism - Genitourinary Disorders - Merck ... … Read more »

Hypogonadism is a disorder where the testes in men and ovaries in women do not work correctly. It can be very distressing. Thanks to the discovery and development of gender-specific hormone treatments, men, and women with hypogonadism can lead a healthy life. Hypogonadism is the clinical manifestation of the impaired function of the gonads, which in men are the testes and in women are the ovaries. Individual patients have hypogonadism from birth, while others may develop the condition later in their life. The disease has different features in males and females, before and after the onset of puberty. If onset is in pre-pubertal boys, signs, and symptoms of lack of testicular function, include a change of male hair distribution, including facial, chest, and axillary hair, poor development of skeletal muscles, and disturbance of bone growth resulting in abnormally long arms and legs. Blood levels of the male hormone testosterone are low. Also observed are missing laryngeal enlargement, failure of vocal chord thickening, and alterations in body fat distribution. When hypogonadism occurs in males after puberty, low concentration of testosterone in the blood causes lack of energy, weakness, lethargy and diminished sexual function, reduced bone mass and often anemia. In girls … Read more »